University of South Carolina · Columbia, SC

How does the brain make meaning?

We study concepts, language, and the neural systems that let us understand the world.

Meaning is a whole-brain achievement.

DeLab investigates the brain bases of language, especially meaning and semantics. We ask how concepts are represented, how language draws on perception and action, and what changes when these systems are affected by disease or injury.

Our current questions ↓
01

Concepts & semantics

How are concepts represented and processed in the brain? We examine the relation between conceptual knowledge and perception–action systems.

02

Language in the wild

We study how the brain processes time, space, action, metaphor, and naturalistic language.

03

Brain health & recovery

Our work examines semantic processing in stroke and Parkinson’s disease, with an eye toward improving outcomes.

A brain transitioning into an abstract language-model network

Brains and language models, in conversation.

We study what large language models can reveal about human conceptual knowledge—and where their representations meaningfully diverge from the brain.

From behavior to brain networks.

We connect complementary methods to answer questions at multiple levels of analysis.

Curious minds,
shared questions.

Meet the people who make DeLab a collaborative place to think, test, and discover.

Meet the lab →
Members of Desai Lab at a lab gathering
Ideas travel further in good company.
fMRI suite at the University of South Carolina
Research infrastructure for questions at every scale.

A campus built for curiosity.

DeLab is part of a vibrant research community at the University of South Carolina, where interdisciplinary collaboration moves ideas from question to discovery.

Explore the USC campus ↗
McKissick Museum on the University of South Carolina campusOak tree on the University of South Carolina campus

Ideas made public.

Selected recent work from the lab.

Data & tools for discovery.

Selected datasets and research software from the lab are available for public use through the Open Science Framework.

Explore resources ↗

Make meaning with us.

We welcome students and researchers with interests in concept representation, semantics, psycholinguistics, cognitive psychology, cognitive neuroscience, and computational approaches.

Undergraduate research assistant positions are anticipated beginning Fall 2027.

Get in touch →